Standardized phytonutrient matrices and plant extracts engineered to the highest pharmacopoeial benchmarks.
CAS 138-52-3, chemically designated as 2-(Hydroxymethyl)phenyl-β-D-glucopyranoside and commonly known as Salicin, is a naturally occurring β-glucoside extracted predominantly from the bark of the Salix (willow) species. In the contemporary chemical and pharmaceutical industries, Salicin serves as a pivotal substrate, natural bioactive compound, and biological benchmark marker.
Historically recognized as the natural evolutionary precursor to modern acetylsalicylic acid (aspirin), CAS 138-52-3 has experienced a major commercial renaissance. This resurgence is fueled by a global consumer transition towards plant-derived therapeutic agents, bio-based cosmetics, and clean-label functional foods. The current macroeconomic data highlights a compound annual growth rate (CAGR) of over 6.2% for natural anti-inflammatory compounds, placing Salicin at the forefront of this industrial shift.
As regulatory agencies worldwide restrict synthetic additives and prioritize sustainable manufacturing practices, global industrial buyers look to secure stable, high-volume supplies of ethically sourced, highly standardized CAS 138-52-3. For key actors in the pharmaceutical, nutraceutical, and topical dermatological formulation fields, selecting a manufacturing partner with verified technical credentials, advanced green extraction systems, and secure supply chains is essential.
Salicin Purity (HPLC)
Traceable Supply Chain
Standard Certified
Exporting Nations
Establishing benchmarks in phytochemistry through clean extraction, state-of-the-art analytical validation, and vertical integration.
Our core strength lies in our vertically integrated process, giving us complete control from seed to extract. We partner with a network of certified organic and sustainably managed farms to ensure the absolute integrity and chemical profile of every raw material batch.
Our state-of-the-art production facility utilizes eco-friendly extraction methodologies. By utilizing subcritical/supercritical extraction and pressurized water-based purification systems, we isolate bioactive molecules like CAS 138-52-3 without hazardous residues.
Every single batch undergoes exhaustive analytical testing. Equipped with modern HPLC, GC-MS, and ICP-MS systems, our in-house lab provides complete documentation (CoA) for heavy metals, pesticides, active assays, and microbial profiles.
How we bridge the gap between biological raw materials and standardized industrial inputs.
Quality and safety are non-negotiable. Every batch undergoes rigorous testing in our in-house laboratories, equipped with HPLC, GC-MS, and other advanced analytical instruments. We guarantee compliance with stringent international standards, including ISO, NSF, cGMP, and related certifications. Our commitment to transparency means you receive comprehensive Certificates of Analysis (CoA) for every product, ensuring traceability and peace of mind.
It’s one thing to just meet the regulations when providing ingredients, but when an ingredient supplier exceeds those standards and imposes even higher ones in its products, that is a sign of a company who cares. Andy Biotech takes extra steps to ensure that our independent third-party laboratory-tested ingredients you want meet our standards as well as your own.
Our extensive portfolio features a wide range of standardized extracts, ratio extracts, and custom blends tailored to specific formulations. Whether you need Echinacea for immune support, Turmeric with high curcuminoid content, or innovative botanical blends for skincare, our technical team works closely with you to deliver exactly what your product requires. Andy Biotech provides high quality Ginkgo Biloba Extract, Lycopene Tomato Extract, Lutein Marigold Extract, Aloe Vera Gel Freeze Dried powder, Aloe Vera Extract, and other natural ingredients.
We source wild and sustainably cultivated willow bark, identifying high-yield cultivars containing peak levels of naturally occurring Salicin.
Water-ethanol low-temperature reflux extraction processes preserve the sensitive β-glucoside bonds, preventing thermal degradation of the active CAS 138-52-3 molecules.
Separation of polyphenols, tannins, and other pigments to reach target concentrations of Salicin, varying from 15% to 98% pure crystalline powders.
Executed inside GMP Class 100,000 cleanrooms, yielding a highly stable, white, crystalline powder with excellent solubility profile.
Maintaining chemical stability and consistency of active components is our primary focus. Synthetic alternatives often lack the complex synergistic trace compounds present in naturally derived CAS 138-52-3, which are crucial for bio-absorption and gastrointestinal tolerance.
Our standard specification matrix for industrial grade CAS 138-52-3 includes:
| Parameter | Specification Benchmark |
|---|---|
| Assay (by HPLC) | 15.0% to 98.0% D-(-)-Salicin |
| CAS Number | 138-52-3 |
| Melting Point | 197°C - 200°C |
| Loss on Drying | ≤ 1.0% |
| Heavy Metals (Pb, As, Hg, Cd) | ≤ 10 ppm total |
From OTC joint-comfort formulations to innovative anti-acne skincare lines, Salicin's versatility is driving progress across multiple sectors.
Salicin functions as a natural modulator of inflammatory pathways via the inhibition of cyclooxygenase (COX) activity. In Europe and North America, B2B brands formulate CAS 138-52-3 in combination with Glucosamine, Chondroitin, and Boswellia for active lifestyle and joint health supplements, avoiding the common stomach irritation associated with synthetic aspirin.
In topical cosmetic applications, Salicin acts as a natural precursor to salicylic acid. Its natural enzymatic conversion provides skin-soothing, exfoliating, and sebum-regulating properties. Brands formulate it in premium anti-aging creams, blemish-control serums, and sensitive skin toners to promote gentle cellular turnover without causing skin peeling.
In chemical synthesis and pharmacological modeling, pure CAS 138-52-3 serves as a valuable reference compound and starting material. It plays an important role in developing next-generation anti-inflammatory agents, offering a biological model for balancing therapeutic benefits with gastrointestinal protection.
Andy was born in a small village close to Hanjiang River in Hanzhong Shaanxi province, China. Thirty years ago, when she was still a little child, she caught a cold, but the medical services were not available unless the family crossed over high mountains to find a hospital. Thus, Andy's grandfather first used Echinacea leaves soaked in water for her treatment, then he dug Echinacea root and shredded into pulp and squeezed the liquid for Andy to drink one spoon every two hours. Andy recovered after this treatment.
As a child, Andy watched his grandfather harness the healing power of plants in his humble garden. His ancient herbal remedies were not just treatments; they were magic. That early wonder blossomed into a profound passion for plant extracts and a deep respect for nature’s wisdom. From that time on, little Andy swore that he would help to spread all herbs all over the world to give benefit to more people.
This personal journey is the heart of Andy Biotech. It’s why Andy Biotech are dedicated to researching and delivering the purest, most effective botanical solutions for modern wellness. Andy’s lifelong vow is to honor that tradition by innovating for a healthier future, empowering lives through the timeless power of plants.
Navigating the complex landscape of international regulatory frameworks to ensure reliable product delivery.
We comply fully with regional regulations, including US FDA regulations for dietary supplements, EFSA novel food guidelines, and Chinese cosmetic safety standards. All our botanical facilities are audited to ensure low microbiological and residual solvent levels, ensuring compliance in every target market.
To reduce shipping times, we coordinate global logistics with regional distribution hubs. Our specialized climate-controlled storage maintains product stability, preventing degradation from moisture or heat fluctuations during transit.
Our regulatory team prepares all necessary documents, including Health Certificates, Phytosanitary Certificates, allergen statements, BSE/TSE-free declarations, and Kosher/Halal certifications, ensuring smooth customs clearance.
Independent verification and international standards compliance validating our manufacturing processes.
Answers to common technical, regulatory, and formulation questions from procurement officers and R&D teams.
Our Salicin is derived from sustainable species of the Salix (willow) genus, including Salix alba L. and Salix purpurea L. We avoid synthetic starting materials to ensure our product remains completely natural and bio-based.
We supply standard specifications, including 15%, 25%, 50%, and highly purified 98% crystalline D-(-)-Salicin. Customized extract concentrations can be developed upon request to meet specific formulation requirements.
Salicin is gentler on the skin barrier. Once applied topically, it converts slowly into salicylic acid within the skin, providing long-lasting exfoliating and anti-acne benefits with a lower risk of redness or irritation.
Every shipment includes a detailed batch Certificate of Analysis (CoA) containing HPLC purity test results, heavy metal limits, residual solvent levels, and microbial assay counts. Third-party testing reports are also available upon request.
Partnering with global manufacturers to supply safe, clean-label raw materials.
Andy Biotech
