Premium grade bio-active raw materials manufactured to the highest cGMP guidelines under rigorous traceabiliy protocols.
A comprehensive analysis of catalytic hydrogenation, metabolic advantages, stability factors, and formulation solutions.
Tetrahydrocurcuminoids (THC) are the primary active metabolites of curcuminoids, synthesized through the precise catalytic hydrogenation of curcumin extracted from the rhizomes of turmeric (Curcuma longa L.). Unlike traditional curcuminoids, which exhibit a strong yellow pigment that limits cosmetic applications due to staining properties, THC is virtually white/colorless. This chemical transition resolves the organoleptic challenges while retaining—and often surpassing—the biological efficacy of standard curcumin.
Under clinical investigation, Tetrahydrocurcumin (CAS 36062-04-1) demonstrates superior stability, enhanced bioavailability, and intensified antioxidant properties compared to parent curcumin. The conversion pathway replaces the double bonds of the heptadiene-dione system with single bonds, rendering the compound highly resistant to physiological and environment-induced degradation.
Primary Efficacy Profile: Tyrosinase inhibition (skin whitening potency exceeding arbutin and kojic acid), lipid peroxidation prevention, free radical scavenging (DPPH and hydroxyl clearance), and down-regulation of pro-inflammatory cytokines such as TNF-α and IL-6.
| Chemical Name | 1,7-Bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione |
| CAS Registry Number | 36062-04-1 |
| Molecular Formula | C21H24O6 |
| Molecular Weight | 372.41 g/mol |
| Assay (HPLC) | ≥ 98.0% (White to Off-White Powder) |
How international buyers mitigate quality risks and secure premium-grade biological supplies in China.
Many lower-tier factories offer Tetrahydrocurcumin that retains a yellowish/beige hue. High-end cosmetic formulations require absolute off-white or white powder (98% minimum HPLC purity) to avoid staining products and ensure compatibility with clean cosmetic bases. Our purification process removes trace intermediate hydrogenated byproducts.
The synthesis of THC requires heavy metal catalysts like Palladium (Pd) or Platinum (Pt). Global regulatory bodies impose severe limits on residual catalyst metals. Top-tier manufacturers must deploy ICP-MS testing to guarantee heavy metal levels fall below 10ppm, and catalyst residues are virtually undetectable.
To transition curcumin to Tetrahydrocurcumin, solvents like ethyl acetate, ethanol, and acetone are utilized. Global pharmaceutical and nutraceutical buyers require strict compliance with USP <467> or EP guidelines, ensuring volatile organic compounds are stripped to parts-per-million thresholds.
Addressing the inherent hydrophobicity and absorption challenges of raw biological actives.
Standard THC exhibits poor water solubility, limiting its integration in liquid cosmetic serums and beverages. We utilize advanced micro-emulsification technology to generate 10% water-dispersible liquid concentrates. These micro-emulsions ensure crystal-clear dilutions without sedimentation or phase separation.
To enhance dermal penetration and optimize sustained release, our liposomal delivery system encloses Tetrahydrocurcumin within phospholipid bilayers. This increases cellular uptake by up to 400%, stabilizes the active against UV-induced oxidation, and minimizes irritancy in sensitive skin formulations.
Designed primarily for functional solid beverages, tablets, and hard-gel capsules. By spray-drying THC with food-grade cyclodextrins, we construct molecular shields that hide bitter tastes, improve powder flowability, prevent oxidation, and increase gastrointestinal release efficiency.
Andy Biotech: Your Trusted Partner in Plant Extract Solutions
Andy Biotech is a leading manufacturer and supplier of premium-quality, scientifically-validated plant extracts for the food, beverage, nutraceutical, cosmetic, and pharmaceutical industries. Founded on a commitment to purity, potency, and innovation, we bridge the gap between nature’s potential and your product development goals.
Our core strength lies in our vertically integrated process, which gives us complete control from seed to extract. We partner with a network of certified organic and sustainably managed farms to ensure the integrity of every raw material. Our state-of-the-art extraction facilities employ advanced technologies, including supercritical solvent and water-based methods, to preserve the full spectrum of bioactive compounds without compromising on environmental responsibility.
Quality and safety are non-negotiable. Every batch undergoes rigorous testing in our in-house laboratories, equipped with HPLC, GC-MS, and other advanced analytical instruments. We guarantee compliance with stringent international standards, including ISO, NSF, cGMP, and related certifications. Our commitment to transparency means you receive comprehensive Certificates of Analysis (CoA) for every product, ensuring traceability and peace of mind.
Andy was born in a small village close to Hanjiang River in Hanzhong Shaanxi province, China. Thirty years ago, when she was still a little child, she caught a cold, but the medical services were not available unless the family crossed over high mountains to find a hospital. Thus, Andy's grandfather first used Echinacea leaves soaked in water for her treatment, then he dug Echinacea root and shredded into pulp and squeezed the liquid for Andy to drink one spoon every two hours. Andy recovered after this treatment.
As a child, Andy watched his grandfather harness the healing power of plants in his humble garden. His ancient herbal remedies were not just treatments; they were magic. That early wonder blossomed into a profound passion for plant extracts and a deep respect for nature’s wisdom. From that time on, little Andy swore that he would help to spread all herbs all over the world to give benefit to more people.
This personal journey is the heart of Andy Biotech. It’s why Andy Biotech are dedicated to researching and delivering the purest, most effective botanical solutions for modern wellness. Andy’s lifelong vow is to honor that tradition by innovating for a healthier future, empowering lives through the timeless power of plants.
Quality and safety are non-negotiable. Every batch undergoes rigorous testing in our in-house laboratories, equipped with HPLC, GC-MS, and other advanced analytical instruments. We guarantee compliance with stringent international standards, including ISO, NSF, cGMP, and related certifications. Our commitment to transparency means you receive comprehensive Certificates of Analysis (CoA) for every product, ensuring traceability and peace of mind.
It’s one thing to just meet the regulations when providing ingredients, but when an ingredient supplier exceeds those standards and imposes even higher ones in its products that is a sign of a company who cares. Andy Biotech takes extra steps to ensure that our independent third-party laboratory-tested ingredients you want meet our standards as well as your own.
Our extensive portfolio features a wide range of standardized extract, ratio extract, and custom blends tailored to specific formulations. Whether you need Echinacea for immune support, Turmeric with high curcuminoid content, or innovative botanical blends for skincare, our technical team works closely with you to deliver exactly what your product requires. Andy Biotech provide high quality Ginkgo Biloba Extract, Lycopene Tomato Extract, Lutein Marigold Extract, Aloe Vera Gel Freeze Dried powder Aloe Vera Extract and other natural ingredients.
Aligning with green chemistry and biotech transformations over the next decade.
Transitioning from traditional carbon-supported heavy metal catalysts to advanced enzymatic biocatalysis. Using naturally occurring reductases, we can achieve high-efficiency conversion of curcumin to Tetrahydrocurcuminoids without residual metal elements or organic solvents, lowering energy footprint by 40%.
Developing next-generation organic lipids and silica-based plant matrices. This allows Tetrahydrocurcumin to dissolve instantly in aqueous formulas without chemical solubilizers, keeping the ingredient label completely "clean" for premium cosmetic brands.
Co-processing Tetrahydrocurcumin with natural synergistic molecules like Ferulic Acid and Resveratrol in a single micro-particle crystal. This optimizes antioxidant cascade mechanisms and offers formulation simplicity for cosmetic engineers.
Expert answers to the most common technical questions asked by global procurement directors and R&D chemists.
Explore our highly standardized range of plant extracts and organic functional powders.
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