An in-depth scientific analysis of Chrysin—its structural characteristics, physiological mechanisms, extraction methodologies, and international procurement standards.
Chrysin (CAS 480-40-0), chemically known as 5,7-Dihydroxy-2-phenyl-4H-chromen-4-one or 5,7-dihydroxyflavone, is a naturally occurring flavone subclass polyphenol compound found in high concentrations in Passiflora coerulea, honey, propolis, and some woody forest species.
In clinical and bio-nutritional research, Chrysin is renowned for its diverse pharmacological profile. Its physiological benefits include serving as a competitive inhibitor of human aromatase (preventing the conversion of androgens to estrogens), demonstrating potent radical scavenging activity, acting as an anti-inflammatory agent through down-regulation of NF-κB pathways, and exhibiting neuroprotective and anti-mutagenic parameters.
"The molecular architecture of Chrysin, featuring hydroxyl groups at positions C5 and C7, dictates its strong hydrogen-donating capacity and key interactions with human steroidogenic enzymes, making it a highly sought-after compound in sports pharmacology and age-management therapeutics."
| Chemical & Physical Specifications | |
|---|---|
| Chemical Name | 5,7-Dihydroxyflavone (Chrysin) |
| CAS Registry Number | 480-40-0 |
| Molecular Formula | C15H10O4 |
| Molecular Weight | 254.24 g/mol |
| Assay Purity (HPLC) | ≥ 98.0% (Pharma / Food Grade) |
| Melting Point Range | 285 °C to 290 °C |
| Solubility Profile | Soluble in Alkaline Solutions, DMSO, and DMF; Poorly soluble in water. |
| Appearance | Light Yellow Crystalline Powder |
Unveiling the structural, logistical, and technical advantages that enable Chinese manufacturing plants to maintain absolute market leadership.
China's unique climate geography (particularly the Shaanxi Qinling mountainous range) permits intensive cultivation of high-yield botanical species, ensuring a continuous, non-interrupted upstream biomass pipeline for extraction.
Equipped with supercritical fluid extraction (SFE) units, high-performance preparative chromatography, and multi-stage crystallization systems, local plants consistently achieve ≥98% purity while keeping heavy metal and pesticide levels below detection thresholds.
Chinese industrial parks offer strong chemical clustering, efficient energy pipelines, and low labor-to-production overheads. These structural cost benefits allow suppliers to offer competitive pricing on bulk purchases of Chrysin.
A deep dive into our company values, production standards, and quality management frameworks that set the benchmark for botanical extraction.
Andy Biotech is a leading manufacturer and supplier of premium-quality, scientifically-validated plant extracts for the food, beverage, nutraceutical, cosmetic, and pharmaceutical industries. Founded on a commitment to purity, potency, and innovation, we bridge the gap between nature’s potential and your product development goals.
Our core strength lies in our vertically integrated process, which gives us complete control from seed to extract. We partner with a network of certified organic and sustainably managed farms to ensure the integrity of every raw material. Our state-of-the-art extraction facilities employ advanced technologies, including supercritical solvent and water-based methods, to preserve the full spectrum of bioactive compounds without compromising on environmental responsibility.
Quality and safety are non-negotiable. Every batch undergoes rigorous testing in our in-house laboratories, equipped with HPLC, GC-MS, and other advanced analytical instruments. We guarantee compliance with stringent international standards, including ISO, NSF, cGMP, and related certifications. Our commitment to transparency means you receive comprehensive Certificates of Analysis (CoA) for every product, ensuring traceability and peace of mind.
It’s one thing to just meet the regulations when providing ingredients, but when an ingredient supplier exceeds those standards and imposes even higher ones in its products, that is a sign of a company that cares. Andy Biotech takes extra steps to ensure that our independent third-party laboratory-tested ingredients meet our standards as well as your own.
Andy Biotech Extraction Facility - Certified Cleanroom Environment
In-House Analytical Verification
Equipped with HPLC, UV-Vis, and Gas Chromatography for real-time monitoring of extraction efficiency.
Exceeding International Regulatory Limits
We run our facilities according to rigorous internal policies that exceed basic FDA and EMA expectations.
Custom Ratios & Specialized Blends
Andy Biotech provides high-quality Ginkgo Biloba Extract, Lycopene Tomato Extract, Lutein Marigold Extract, and Aloe Vera Gel Freeze Dried Powder.
How a passion for natural medicine grew into a global botanical extract enterprise supplying CAS 480-40-0 to leading brands worldwide.
Andy was born in a small village close to the Hanjiang River in Hanzhong, Shaanxi province, China. Thirty years ago, when she was still a little child, she caught a cold, but medical services were not available unless her family crossed over high mountains to find a hospital. Thus, Andy's grandfather first used Echinacea leaves soaked in water for her treatment, then he dug Echinacea root, shredded it into pulp, and squeezed the liquid for Andy to drink one spoon every two hours. Andy recovered after this treatment.
As a child, Andy watched her grandfather harness the healing power of plants in his humble garden. His ancient herbal remedies were not just treatments; they were magic. That early wonder blossomed into a profound passion for plant extracts and a deep respect for nature’s wisdom. From that time on, little Andy swore that she would help spread all herbs all over the world to benefit more people.
This personal journey is the heart of Andy Biotech. It is why Andy Biotech is dedicated to researching and delivering the purest, most effective botanical solutions for modern wellness. Andy’s lifelong vow is to honor that tradition by innovating for a healthier future, empowering lives through the timeless power of plants.
How global brands integrate CAS 480-40-0 into target formulations, fitness trends, and anti-aging cosmetics.
Widely used as an active ingredient in testosterone boosters and post-workout recovery formulas. By inhibiting the aromatase enzyme, Chrysin supports healthy testosterone-to-estrogen balance, enhancing muscle growth and athletic stamina.
In cosmetics, Chrysin is formulated into eye creams to target dark circles and puffiness. It works by stimulating UGT1A1, an enzyme that helps clear pigmented bilirubin deposits under the skin, revealing a brighter, firmer appearance.
Recent scientific work indicates Chrysin behaves as a natural ligand for central GABA-A benzodiazepine receptors. This interaction produces mild anxiolytic and sleep-supportive benefits without sedative side effects.
One historic bottleneck of raw Chrysin is its low intestinal bioavailability due to rapid phase-II metabolism. Andy Biotech addresses this limitation through structural solutions: we offer customized co-milling with black pepper-derived Piperine (which inhibits glucuronidation) and formulation with Cyclodextrin complexes. These enhancements increase systemic absorption by up to 250%.
Global standards of documentation, quality verification, and analytical validation.
Answers to critical questions regarding supply logistics, analytical testing, regulatory profiles, and payment terms for bulk orders.
Our Chrysin is predominantly extracted and purified from the natural raw stems and flowers of Passiflora coerulea (Blue Passion Flower) or derived via high-efficiency semi-synthesis from premium, traceable natural flavin compounds. We provide both 100% naturally extracted grades and high-efficiency cost-effective grades depending on client formulation requirements.
Every batch undergoes a standard suite of analytical tests. We run High-Performance Liquid Chromatography (HPLC) to verify active ingredient assay values, Gas Chromatography-Mass Spectrometry (GC-MS) for solvent residues and pesticides, and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) to guarantee heavy metal profiles are well within international limits (Pb <3ppm, As <1ppm, Hg <0.1ppm, Cd <1ppm).
Our standard shipping package is a 25 kg fiber drum with double-layered food-grade polyethylene interior bags. For trial runs and laboratory testing, our MOQ starts at 1 kg.
Yes. Our R&D department specializes in custom ratio blending, dry mixing, and compounding. We frequently package custom formulations combining Chrysin with Piperine, Tribulus Terrestris, Saw Palmetto, or Zinc to simplify direct encapsulation for our manufacturing customers.
Andy Biotech
