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Understanding the molecular properties, extraction standards, and botanical origins.
CAS 10236-47-2, commonly known as Naringin, is a major flavanone glycoside naturally occurring in citrus fruits, most prominently extracted from the peel and pulp of *Citrus grandis* (Pomelo) and *Citrus paradisi* (Grapefruit). Chemically designated as 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, this bioactive molecule represents one of the most commercially versatile bioflavonoids globally.
As a premier wholesale supplier and cGMP manufacturer, Andy Biotech utilizes high-precision extraction methods to guarantee minimum assays of 98% Naringin. The crystalline powder exhibits a distinct, clean bitter taste profile which has driven its adoption as a standardized bittering agent, natural antioxidant, and functional modulator in the pharmaceutical, food, beverage, and agricultural industries.
Our vertically integrated supply chain ensures that our raw agricultural biomass is harvested at the peak phytomedicinal concentration window. By utilizing modern chromatography systems, we isolate CAS 10236-47-2 with absolute solvent compliance, conforming to EPA, USP, and EP thresholds.
| Specification Parameter | Test Methodology | Guaranteed Standard Range | Regulatory Compliance |
|---|---|---|---|
| Appearance | Visual Inspection | Light Yellow to Off-White Crystalline Powder | EP / USP Standardized |
| Assay (Naringin Content) | HPLC-DAD (High Performance Liquid Chromatography) | ≥ 95% / ≥ 98% (Dry Basis) | Internal Reference standards |
| Loss on Drying | Gravimetric Method | ≤ 5.0% | USP <731> |
| Heavy Metals (Pb, As, Cd, Hg) | ICP-MS (Inductively Coupled Plasma Mass Spectrometry) | As < 1.0 ppm, Pb < 1.0 ppm, Cd < 0.5 ppm, Hg < 0.1 ppm | Prop 65 & EU Limits |
| Pesticide Residues | GC-MS/MS & LC-MS/MS | Complies with EP 2.8.13 Multi-residue limits | FDA & EC Regulations |
| Total Plate Count | USP <61> Microbial Enumeration | ≤ 1,000 CFU/g | Food & Supplement Grade |
How CAS 10236-47-2 is shaping the clean-label beverage, pharmaceutical, and livestock sectors globally.
In Western consumer markets, the demand for natural alternatives to synthetic bittering agents (such as quinine) has escalated significantly. CAS 10236-47-2 serves as the primary botanical bittering agent in bitter lemon sodas, tonic waters, and digestive liqueurs. Additionally, its properties as a powerful antioxidant and anti-inflammatory modulator make it a popular ingredient in premium cardiovascular and cognitive health supplements.
In the APAC region, particularly across modern commercial farming operations, Naringin is widely used as a natural alternative to synthetic growth promoters. By modulating the gut microflora and reducing systemic inflammation in swine and poultry, CAS 10236-47-2 improves feed conversion ratios (FCR) and enhances livestock immunity, supporting the global transition to antibiotic-free agriculture.
A major commercial application for Naringin is its use as the starting material for the synthesis of Neohesperidin Dihydrochalcone (NHDC, CAS 20702-77-6). NHDC is a high-intensity sweetener and flavor modifier that is roughly 1500-1800 times sweeter than sucrose. Industrial chemical manufacturers rely on a steady supply of high-purity CAS 10236-47-2 to ensure optimal yield and purity in their catalytic hydrogenation processes.
HPLC Purity Standard
Annual Production Capacity
Synthetic Solvent Residue
Exporting Destinations
Specific integration profiles for regional manufacturing, formulation, and commercial markets.
In the United States, dietary supplement brands integrate CAS 10236-47-2 into metabolic enhancers, sports endurance blends, and capillary wellness formulations. Because Naringin is known to inhibit certain CYP450 enzymes (such as CYP3A4), it is utilized to increase the bioavailability of other co-administered botanical compounds. This synergistic action allows sports performance brands to develop highly effective formulations with lower active dosage requirements.
European beverage manufacturers leverage CAS 10236-47-2 to formulate low-sugar tonic waters and non-alcoholic aperitifs. Furthermore, under EU food regulations, Naringin’s strong antioxidant properties are utilized to extend the shelf life of food matrices by preventing lipid peroxidation. This makes it an ideal ingredient for brands seeking to replace synthetic additives like BHA or BHT.
In East Asian cosmetic formulations, Naringin is utilized for its exceptional skin-soothing properties and its ability to inhibit elastase and collagenase enzymes. Formulators integrate CAS 10236-47-2 into anti-aging serums, skin-brightening essences, and UV protection creams to help reduce redness, combat oxidative stress, and maintain dermal elasticity.
How Andy Biotech pushes the limits of eco-friendly, green chemistry to extract CAS 10236-47-2.
The traditional production of Naringin historically relied on harsh organic solvents. Andy Biotech has revolutionized this process by implementing an environmentally responsible Green Water-Ethanol Extraction System.
The future of CAS 10236-47-2 production is focused on increasing molecular precision. Andy Biotech is currently conducting pilot-scale studies on enzymatic transglycosylation. This process uses specific rhamnosidases to selectively modify glycosidic bonds, allowing us to produce customized neohesperidin variants and enhance the solubility of Naringin in water. This will enable drink manufacturers to formulate crystal-clear, bitter functional beverages without sediment issues.
Why sourcing Naringin from our specialized Chinese facility ensures unparalleled quality and pricing stability.
China is home to some of the largest Citrus grandis (Pomelo) cultivation regions in the world, particularly in the Shaanxi, Sichuan, and Fujian provinces. Andy Biotech's manufacturing facilities are located near these agricultural centers. This proximity reduces transit times for raw biomass, prevents natural degradation of the active ingredients, and lowers raw material acquisition costs.
Our modern factory utilizes automated, continuous production lines. Automated control systems maintain precise control over temperature, pressure, and solvent flow rates. This level of automation reduces human error, guarantees batch-to-batch consistency, and lowers operational overhead. As a result, we can offer competitive wholesale pricing without compromising on quality.
Located near major shipping hubs, Andy Biotech provides comprehensive logistics support, including ocean freight, air cargo, and express shipping. We handle all export documentation, custom clearances, and phytosanitary declarations. This streamlined process minimizes delays and ensures that CAS 10236-47-2 shipments arrive safely at your facility.
Andy Biotech: Your Trusted Partner in Plant Extract Solutions
Andy Biotech is a leading manufacturer and supplier of premium-quality, scientifically-validated plant extracts for the food, beverage, nutraceutical, cosmetic, and pharmaceutical industries. Founded on a commitment to purity, potency, and innovation, we bridge the gap between nature’s potential and your product development goals.
Our core strength lies in our vertically integrated process, which gives us complete control from seed to extract. We partner with a network of certified organic and sustainably managed farms to ensure the integrity of every raw material. Our state-of-the-art extraction facilities employ advanced technologies, including supercritical solvent and water-based methods, to preserve the full spectrum of bioactive compounds without compromising on environmental responsibility.
Our extensive portfolio features a wide range of standardized extract, ratio extract, and custom blends tailored to specific formulations. Whether you need Echinacea for immune support, Turmeric with high curcuminoid content, or innovative botanical blends for skincare, our technical team works closely with you to deliver exactly what your product requires.
Andy Biotech provides high quality Ginkgo Biloba Extract, Lycopene Tomato Extract, Lutein Marigold Extract, Aloe Vera Gel Freeze Dried powder, Aloe Vera Extract, and other natural ingredients to the food, health, and nutraceutical industries.
Andy was born in a small village close to Hanjiang River in Hanzhong Shaanxi province, China. Thirty years ago, when she was still a little child, she caught a cold, but the medical services were not available unless the family crossed over high mountains to find a hospital. Thus, Andy's grandfather first used Echinacea leaves soaked in water for her treatment, then he dug Echinacea root and shredded into pulp and squeezed the liquid for Andy to drink one spoon every two hours. Andy recovered after this treatment.
As a child, Andy watched his grandfather harness the healing power of plants in his humble garden. His ancient herbal remedies were not just treatments; they were magic. That early wonder blossomed into a profound passion for plant extracts and a deep respect for nature’s wisdom. From that time on, little Andy swore that he would help to spread all herbs all over the world to give benefit to more people.
This personal journey is the heart of Andy Biotech. It’s why Andy Biotech is dedicated to researching and delivering the purest, most effective botanical solutions for modern wellness. Andy’s lifelong vow is to honor that tradition by innovating for a healthier future, empowering lives through the timeless power of plants.
Three core commitments that define our operational standards.
Quality and safety are non-negotiable. Every batch undergoes rigorous testing in our in-house laboratories, equipped with HPLC, GC-MS, and other advanced analytical instruments. We guarantee compliance with stringent international standards, including ISO, NSF, cGMP, and related certifications. Our commitment to transparency means you receive comprehensive Certificates of Analysis (CoA) for every product, ensuring traceability and peace of mind.
It’s one thing to just meet the regulations when providing ingredients, but when an ingredient supplier exceeds those standards and imposes even higher ones in its products that is a sign of a company who cares. Andy Biotech takes extra steps to ensure that our independent third-party laboratory-tested ingredients you want meet our standards as well as your own.
Our extensive portfolio features a wide range of standardized extract, ratio extract, and custom blends tailored to specific formulations. Whether you need Echinacea for immune support, Turmeric with high curcuminoid content, or innovative botanical blends for skincare, our technical team works closely with you to deliver exactly what your product requires.
Our facility holds certifications to meet global regulatory and consumer standards.
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