Flavanone-rich plants, such as naringin, hesperidin, and neohesperidin, have long been known to have anti-inflammatory properties. In animal models, naringin reduces inflammatory signaling factors like IL-8, IL-6, iNOS, TNF-a, and Nrf2.

It also plays the most important role in traditional Chinese medicine formulas like "painopowder" for acute inflammation alleviation.

Naringin inhibits malignancies by regulating cellular signaling cascades. This includes inhibiting malignant cell growth, inducing apoptosis, arresting the cell cycle, and regulating oxidative stress, inflammatory processes, and angiogenesis.

At concentrations of 250–2000 M, it promoted dose-dependent cell apoptosis in cervical cancer cells (SiHa).

Naringin regulates glucose, fatty acid, and cholesterol metabolism, proving beneficial for hyperglycaemic and obese models. It enhances the expression of angiopoietin-1 and collagen-1, promoting angiogenesis in diabetic foot ulcers.

Furthermore, it normalizes cardiovascular dysfunction, including systolic blood pressure and ventricular diastolic dysfunction.

Naringin enhances the hepatic antioxidant system and the metabolism of hepatotoxic substances. It exhibits protection against food genotoxins like PhIP and cooked food mutagens, lessening induced genotoxicity in human liver segments.

It also increases ethanol and lipid metabolism, reducing necrosis, steatosis, and fibrosis in alcoholic liver disease models.