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Quercetin (3,3',4',5,7-pentahydroxyflavone) is a prominent polyphenol belonging to the subclass of flavonols. Within the industrial phytochemical supply chain, the flower buds of Sophora japonica L. (Huai Mi) stand as the richest and most sustainable botanical repository of this bioactive molecule. The raw plant material naturally accumulates high concentrations of Rutin (quercetin-3-rutinoside), which acts as the precursor for industrial Quercetin synthesis via controlled hydrolytic pathways.
| Standard Specification Parameter | Quercetin Dihydrate (USP/EP Standards) | Quercetin Anhydrous (High Purity Grade) |
|---|---|---|
| Assay (HPLC, Dry Basis) | ≥ 95.0% or ≥ 98.0% | ≥ 98.0% |
| Botanical Origin | Sophora japonica L. (Flower bud) | Sophora japonica L. (Flower bud) |
| CAS Number | 117-39-5 (Dihydrate: 6151-25-3) | 117-39-5 |
| Loss on Drying | 9.5% – 12.0% | ≤ 4.0% |
| Heavy Metals (Pb, Cd, As, Hg) | ≤ 10 ppm total (USP compliant) | ≤ 5 ppm total (EP compliant) |
| Pesticide Residues | USP <561> / EC 396/2005 compliant | EC 396/2005 Compliant (Pesticide Free) |
The conversion of Sophora-derived Rutin into high-purity Quercetin aglycone requires precise reaction conditions. The industrial process is carried out through enzymatic hydrolysis or controlled acid-catalyzed cleavage. In acid hydrolysis, the glycosidic linkages between the quercetin aglycone and the disaccharide rutinose are broken under low pH (typically using food-grade hydrochloric or sulfuric acids) at temperatures ranging between 70°C and 90°C. Following the reaction, the precipitate is subjected to multi-stage crystallization using food-grade ethanol and purified water, ensuring the elimination of residual solvent contaminants and heavy metal complexes.
Modern green technology utilized during the primary isolation steps to eliminate lipophilic impurities without leaving chemical solvent residues in the final biomass.
An advanced biotech roadmap utilizing alpha-rhamnosidase and beta-glucosidase to yield high-bioavailability Quercetin under mild, environmentally safe conditions.
Employs automated thermodynamic control to design specific crystal habits and optimize particle size (mesh sizes available from 80 to 200 mesh) for supplement formulations.
Global health and wellness consumer demands have transformed Quercetin from a standard antioxidant into a cornerstone active ingredient for targeted therapeutic applications. Andy Biotech provides comprehensive macro-industry solutions tailored to specific commercial sectors:
Optimized for immune-boosting capsules, zinc ionophore formulas, and respiratory health blends. Our raw material integrates seamlessly with Vitamin C, Bromelain, and Zinc to produce synergetic physiological benefits.
Utilized for its clinically validated anti-inflammatory and soothing properties. Micro-fine Quercetin is designed for topical creams to protect dermal structures against UV-induced oxidative stress and premature aging.
Water-dispersible formulations and complexes engineered for energy drinks, wellness shots, and recovery foods, satisfying consumers' search for functional, plant-derived clean labels.
By integrating advanced automation and raw material origin management, Andy Biotech guarantees a stable, highly efficient, and vertically controlled supply of Sophora japonica extract. Our factory model is designed to navigate global economic volatility and ensure uninterrupted delivery of high-volume orders.
Our automated production lines feature continuous countercurrent extraction (CCE) and online spectroscopic monitoring systems. This guarantees consistent active compound density between batches while slashing water consumption by 40% and power consumption by 30%. Operating out of China's primary Sophora growing region in Shaanxi province, we secure direct access to top-grade botanical crops. This logistical proximity insulates our clients from raw material price shocks and logistics delays.
Andy Biotech is a leading manufacturer and supplier of premium-quality, scientifically-validated plant extracts for the food, beverage, nutraceutical, cosmetic, and pharmaceutical industries. Founded on a commitment to purity, potency, and innovation, we bridge the gap between nature’s potential and your product development goals.
Our core strength lies in our vertically integrated process, which gives us complete control from seed to extract. We partner with a network of certified organic and sustainably managed farms to ensure the integrity of every raw material. Our state-of-the-art extraction facilities employ advanced technologies, including supercritical solvent and water-based methods, to preserve the full spectrum of bioactive compounds without compromising on environmental responsibility.
Quality and safety are non-negotiable. Every batch undergoes rigorous testing in our in-house laboratories, equipped with HPLC, GC-MS, and other advanced analytical instruments. We guarantee compliance with stringent international standards, including ISO, NSF, cGMP, and related certifications. Our commitment to transparency means you receive comprehensive Certificates of Analysis (CoA) for every product, ensuring traceability and peace of mind.
It’s one thing to just meet the regulations when providing ingredients, but when an ingredient supplier exceeds those standards and imposes even higher ones in its products, that is a sign of a company who cares. Andy Biotech takes extra steps to ensure that our independent third-party laboratory-tested ingredients you want meet our standards as well as your own.
Our extensive portfolio features a wide range of standardized extract, ratio extract, and custom blends tailored to specific formulations. Whether you need Echinacea for immune support, Turmeric with high curcuminoid content, or innovative botanical blends for skincare, our technical team works closely with you to deliver exactly what your product requires. Andy Biotech provide high quality Ginkgo Biloba Extract, Lycopene Tomato Extract, Lutein Marigold Extract, Aloe Vera Gel Freeze Dried powder Aloe Vera Extract and other natural ingredients to food, health and nutraceutical industries.
Andy was born in a small village close to Hanjiang River in Hanzhong Shaanxi province, China. Thirty years ago, when she was still a little child, she caught a cold, but the medical services were not available unless the family crossed over high mountains to find a hospital. Thus, Andy's grandfather first used Echinacea leaves soaked in water for her treatment, then he dug Echinacea root and shredded into pulp and squeezed the liquid for Andy to drink one spoon every two hours. Andy recovered after this treatment.
As a child, Andy watched his grandfather harness the healing power of plants in his humble garden. His ancient herbal remedies were not just treatments; they were magic. That early wonder blossomed into a profound passion for plant extracts and a deep respect for nature’s wisdom. From that time on, little Andy swore that he would help to spread all herbs all over the world to give benefit to more people.
This personal journey is the heart of Andy Biotech. It’s why Andy Biotech are dedicated to researching and delivering the purest, most effective botanical solutions for modern wellness. Andy’s lifelong vow is to honor that tradition by innovating for a healthier future, empowering lives through the timeless power of plants.
To serve tier-one global brands in the United States, Europe, and Asia-Pacific, our production facilities and botanical operations strictly comply with key international quality systems. Every shipment of our Sophora japonica extract is accompanied by comprehensive batch documentation, ensuring smooth customs clearance and regulatory audits.
Navigating different chemical regulations is a primary concern for international supplement manufacturers. Andy Biotech provides structured regulatory affairs support, offering full assistance for FDA, EFSA, and regional food safety filings. We proactively tackle compliance challenges such as Ethylene Oxide (ETO) levels, irradiation control, PAH levels (Polycyclic Aromatic Hydrocarbons), and Pyrrolizidine Alkaloids (PAs) limits to meet strict European guidelines.
We supply complete dossiers including MSDS, Allergen Statements, Non-GMO declarations, Kosher & Halal credentials, and BSE/TSE statements with every batch.
In partnership with distribution centers in North America and Western Europe, we offer flexible Just-in-Time (JIT) delivery and localized safety stocks.
Our client partners are welcome to perform full physical or virtual site audits. We offer transparent access to our agricultural and processing logs.
As global focus shifts toward molecular longevity and preventative cellular health, the market for Quercetin is evolving rapidly. Key technological fields where Andy Biotech is focusing its research and development include:
Standard Quercetin is hydrophobic, displaying relatively low intestinal absorption. We are scaling up the production of water-dispersible systems using natural carrier systems like Sunflower Lecithin (Quercetin Phytosomes) to dramatically boost cellular uptake.
We are developing standardized complex matrices that pair Quercetin with other active botanical compounds (like Dasatinib precursors, Fisetin, and Apigenin) targeting cellular senescence and healthy aging markets.
Aligning with global ESG guidelines, we aim to transform our plant extraction units into carbon-neutral facilities by 2028. This will be achieved through solar thermal energy integration and total bio-waste recycling from our processed Sophora japonica leaves and seeds.
Quercetin Dihydrate contains two bound water molecules within its crystal matrix, resulting in a moisture range between 9.5% and 12%. Quercetin Anhydrous is processed to remove these water molecules, keeping residual moisture under 4%. Anhydrous is often favored in moisture-sensitive formulations (like dry blends or multi-ingredient tablets) to prevent the degradation of other active ingredients.
We do not use Ethylene Oxide (ETO) sterilization at any stage of our manufacturing. Microbial reduction is achieved using controlled heat treatment and clean-room technologies. Additionally, our raw Sophora japonica crops are meticulously weeded and monitored at our GAP farms to ensure no wild PA-containing plants are harvested alongside the flowers.
We prioritize clean extraction methods. Our process utilizes food-grade ethanol and pure water. This meets strict European and US regulations for volatile organic solvent residues, keeping them far below USP and EP limits.
Yes. We supply customized particle sizes based on your manufacturing setup. Our standard powder is 80 mesh, but we can micronize it down to 200 mesh for improved absorption, or supply granular formats to optimize high-speed capsule filling lines.
Our Quercetin is stable for 36 months from the date of manufacture when stored in the original unopened container. It should be kept in a cool, dry place away from direct sunlight, moisture, and high temperatures.
In addition to our industry-leading Quercetin solutions, Andy Biotech offers a comprehensive suite of highly bioavailable extracts designed for food, beverage, cosmetics, and wellness formulations.
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